| 25/06/2026 19:00 | | Defensor Sporting Reserve  | 1 - 0 | Colon FC Reserves | T |
| 22/06/2026 20:00 | | Defensor Sporting Reserve | 2 - 1 | Deportivo Maldonado Reserve | T |
| 16/06/2026 01:00 | | Oriental La Paz Reserve | 0 - 2 | Defensor Sporting Reserve | T |
| 08/06/2026 20:30 | | Defensor Sporting Reserve | 1 - 1 | Nacional de Montevideo Reserves | H |
| 03/06/2026 00:00 | | Boston River Reserve | 1 - 4 | Defensor Sporting Reserve | T |
| 29/05/2026 01:00 | | Progreso Reserves | 1 - 3 | Defensor Sporting Reserve | T |
| 18/05/2026 19:30 | | Defensor Sporting Reserve | 1 - 0 | Albion fc Reserves | T |
| 13/05/2026 00:00 | | Central Espanol Reserves | 1 - 1 | Defensor Sporting Reserve | H |
| 06/05/2026 01:30 | | Defensor Sporting Reserve | 2 - 2 | Cerro Largo Reserves | H |
| 29/04/2026 01:30 | | Penarol Reserve | 1 - 0 | Defensor Sporting Reserve | B |
Uruguay